Antagonism by hemoglobin of effects induced by L-arginine in neuromuscular preparations from rats
Nitric oxide (NO)-synthase is present in diaphragm, phrenic nerve and vascular smooth muscle.It has been shown that the NO precursor L-arginine (L-Arg) at the presynaptic level increases the amplitude of muscular contraction (AMC) and induces tetanic fade when the muscle is indirectly stimulated at low and high frequencies, respectively.However, th